Heart failure with preserved ejection fraction – new elements of evidence in the field of pathophysiology and new treatment options
نویسندگان
چکیده
Consistent with the understanding of comorbidity-infl ammation relationship, concomitant diseases and especially metabolic comorbidities are thought to stimulate development severity heart failure preserved ejection fraction through a cascade mechanisms supporting systemic tissue infl leading myocardial fi brosis. Recently, new experimental clinical evidence has emerged that enhances validity verifi es ammatory-profi brotic paradigm. This consists of: (1) infi ltration immunocompetent cells not only due load caused by obesity but also arterial hypertension-induced haemodynamic loading extracellular matrix components (such as basal laminatin interacting laminate); (2) expression in cardiomyocytes inducible nitric oxide synthetase under uence circulating proinfl ammatory cytokines, which leads accumulation degraded proteins myocardium an unfolded protein response; (3) defi ning phenogroups patients distinct profi component machining algorithms; (4) direct association. mediation analysis between comorbidities, biomarkers impaired structure function endothelial adhesion molecules already accumulated early preclinical (CH stage A, B). paves way for future treatment conserved biologics directed against 1) 2) stimulating complete response non-accumulation chiocardia phosphodiesterase inhibitors rigidity titin natriuretic peptide – particular guanylyl cyclase PDE9 (phosphodiesterase 9) 4) molecular cellular regulatory control
منابع مشابه
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment.
Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction (HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF and reduced EF, yet no effective treatment has been identified. While early research focused on the importance of diastolic dysfunction in the pathophysiology of HFpEF, recent studies have revealed that multiple...
متن کاملHeart Failure With Preserved Ejection Fraction
The Journal of the American Osteopathic Association July 2015 | Vol 115 | No. 7 432 From Henry Ford Wyandotte Downriver Cardiology in Brownstown, Michigan (Dr Rogers); West Suburban Medical Center in Oak Park, Illinois (Dr Gundala); Oakwood Southshore Medical Center in Trenton, Michigan (Dr Ramos); and Elmhurst Memorial Hospital in Illinois (Dr Serajian). Drs Gundala and Ramos are in their thir...
متن کاملHeart Failure With Preserved Ejection Fraction
Symptomatic heart failure, despite preserved left ventricular (LV) ejection fraction, is a well-recognized phenomenon. This manifestation of diastolic dysfunction is associated with increased morbidity and mortality and can be attributed to a variety of pathogeneses, including diabetes mellitus, hypertension, infiltrative processes, and obesity. Unlike in systolic heart failure, where LV ejecti...
متن کاملHeart Failure with a Preserved Ejection Fraction: From Pathophysiology to Biomarkers ... and Beyond! HEART FAILURE | REVIEW
More than thirty years ago, it was recognised that signs and symptoms of heart failure may occur in patients in whom the ejection fraction of the left ventricle (LV) is within normal limits. Although originally studied in patients with genuine hypertrophic cardiomyopathy, heart failure with “preserved” LV ejection fraction (HFPEF) has now been recognised in a more common population, which is ch...
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ژورنال
عنوان ژورنال: ????????? ???????????
سال: 2021
ISSN: ['2786-4782', '2786-4774']
DOI: https://doi.org/10.3897/bgcardio.27.e69592